Metabolic alterations associated with T2D are very well characterised by epidemiological and research based mostly experiments. The pathogenesis and progression of T2D is ascribed to 4 mechanisms; elevated advanced glycation close product or service (AGE) development, increased polyol pathway flux, activation of protein kinase C (PKC) isoforms, and enhanced hexosamine https://www.directivepublications.org/journal-of-diabetology-research/