There's a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent discomfort transmission and make analgesia. Consequently, medications like clonidine that concentrate on alpha-2 receptors can influence the transmission of pain. : connected to, served by, or available https://euripidesw713eca3.wikitidings.com/user