There's a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to lessen afferent discomfort transmission and create analgesia. Therefore, drugs like clonidine that concentrate on alpha-2 receptors can impact the transmission of discomfort. This doc doesn't comprise all achievable interactions. https://robertf158vvr0.mappywiki.com/user