From the LSD-certain crystal structure, the facet chain from the lid residue L209EL2 varieties in depth hydrophobic contacts with the two LSD and surrounding residues in TMs III, IV, and V (Figure 4C). If the lid moved aside to reveal the binding pocket in simulation, many of such contacts broke. https://bookmarkpagerank.com/story19584156/lsd-crystal-can-be-fun-for-anyone