In this article, we show that conolidine, a pure analgesic alkaloid used in classic Chinese medicine, targets ACKR3, thus delivering extra proof of the correlation between ACKR3 and ache modulation and opening different therapeutic avenues with the procedure of Serious ache. All emblems, registered emblems and service-marks mentioned on https://bookmarkhard.com/story19735579/the-2-minute-rule-for-what-is-conolidine